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Although, because of species differences, in vivo models are not the best way to study induction of metabolizing enzymes and drug transporters, information can be obtained from them, especially when humanized transgenic animals are used [57]. In humanized CAR transgenic mice, it was shown that the TCM Yin Zhi Huang, a decoction of Yin Chin Artemisia capillaris ; and three other herbs, accelerates the clearance of bilirubin by activation of CAR [71]. Studies with wild-type rats showed induction of CYP2B by Ginkgo biloba extract [72], increased CYP3A expression and activity after exposure to licorice root extract and its natural constituent glycyrrhizin [73], and enhanced activity of GST and UGT after intake of rooibos Aspalathus linearis ; and honeybush Cyclopia intermedia ; teas [74]. These studies, however, give no information about the mechanism behind the induction and the nuclear receptor involved. Careful interpretation of in vivo results is thus necessary because the species differences in nuclear receptors and inductive processes make extrapolation to humans difficult.
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Dr Mike Laker Medical Director, Newcastle Hospitals NHS Trust, Royal Victoria Infirmary, Newcastle-Upon-Tyne Dr George Levvy Lay Representative, Chief Executive, Motor Neurone Disease Association, Northampton Professor Richard Lilford Professor of Clinical Epidemiology, Department of Public Health and Epidemiology, University of Birmingham Professor John Lumley Honorary Consultant, The Ernest Cooke Clinic Microvascular Unit, Great Ormond Street, Bart's and the Royal London NHS Trust, Barbican, London Dr Simon Mitchell Consultant Neonatal Paediatrician, St Mary's Hospital, Manchester Dr Virginia Pearson Chief Executive, South Petherton Hospital, South Somerset PCT Dr Christa Roberts Industry Representative, UK Manager Vascular Intervention, Guidant Ltd. Dr Stephen Saltissi Consultant Cardiologist, Royal Liverpool University Hospital Dr Lindsay Smith General Practitioner, Westlake Surgery, Somerset Mr Mike Spencer General Manager, Clinical Support Services, Cardiff and Vale NHS Trust and cyproheptadine.
Research. The Division of Cardiology continues to build upon its superior clinical services by participating in sponsored clinical research, supporting faculty- and fellow-initiated investigations, and offering community-focused intervention programs under the direction of Division Chief Syed Mohiuddin, MD Stephanie Maciejewski, PharmD serves as the Administrative Director of Research, with Michael Del Core, MD leading the Interventional Research Program and Antonio Reyes, MD leading the Non-Interventional Clinical Trials Program. The Cardiac Center initiated eighteen new research studies during the past year, including phases III and IV pharmaceutical and device trials, as well as investigator-initiated research. Those topics include anemia, heart failure, acute coronary syndromes, hypertension, endothelial function, lipid lowering agents, C-reactive protein, acute MI, and intervention and post-intervention studies. Funded Programs in Minority Cardiovascular Risk Prevention. The Cardiac Center recognized a need to provide educational and preventive programs to the local community and responded with multiple initiatives. These programs enhance Creighton's visibility in the Omaha community and establish the university as a partner willing to share its resources to improve health care in the minority community. Creighton Community Health Center The Cardiac Center of Creighton University Medical Center and Creighton University established the Creighton Community Health Center CCHC ; in an effort to enhance educational opportunities for Creighton students, improve health care services to area underserved populations, and advance the science directed toward reducing, eliminating, or preventing health disparities in minority and underserved populations. Funding for the Community Health Center is balanced between Nebraska Tobacco Settlement Biomedical Research Development funds LB692 ; and Creighton University Health Future Foundation Faculty Development Grants. The center provides outpatient basic medical care encompassing curative and preventative medicine, health promotion and maintenance, education, nutrition, and continuing care evaluation and management for men, women, and children. Our hope is that the center will.
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Name tag distributed to third year medical students on their clinical rotations. Tufts does not identify us as medical students. To find out if the different name tag suffixes made any difference to patients, four student descriptions were tested. Patients were asked to guess the level of experience of each one of the four student descriptors 'medical student, ' 'student physician, ' 'student doctor, ' and 'MD student.' Not surprisingly, patients thought 'medical student' indicated less experience than the other three p .0001 ; * . The authors conclude the obvious, "To emphasize students' lack of experience to patients and make it more difficult for physicians or medical students to verbally introduce students as 'doctors' or 'physicians, ' we think name tags ought to refer to students as 'medical students.'"[20] * A "p-value" is a measure of how likely a finding may have just been due to chance. A value as low as .0001 makes the finding highly statistically significant the cut-off for significance is anything less than .05 by convention.
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Introduction A communication between the internal carotid artery or branches of the external carotid artery and the cavernous sinus leads to the development of a fistula in which the veins are under arterial pressure. Valveless venous intercommunication between the cavernous sinus and the superior ophthalmic vein leads to a transmission of arterial pressure into the veins of the orbit. Proptosis, motility disturbances, pulsating exophthalmos with a bruit ; and suffusion of the globe, sclera and conjunctiva are the hallmarks of a carotid-cavernous fistula. The etiology is most often trauma, but fistulas may occur spontaneously either secondary or atherosclerotic disease or from communications between the dural branches of the external carotid artery and the basilar venous plexus dural AVM ; Objective To present a case of recurrent post clipping CCF which was treated in HUSM via balloon embolisation. Methodology A 20-year-old Malay boy from Gua Musang was first seen by our neurosurgeon in Mei 1998 after he was involved in a motorcycle accident. He was a pillion rider and was involved in head on collision with another motorcycle. Both motorcyclist had a fight. He was hit with a crash helmet on his head. He fainted and was brought to HUSM. A craniectomy was performed to remove the intracranial blood clot. After the operation, he noticed a gradual swelling of his right eye. This was associated with headache , burning sensation and blurring vision Rt ; . Later he noticed redness of the conjunctiva Rt ; . There was no history of body weakness, vomiting, skull fracture, fever, loss of sensation or hearing of an abnormal hissing sound. Examination revealed conjunctival redness, restricted extraoccular movement, reduced vision, pulsating exophthalmus and bruits was heard on auscultation. No evidence of cranial nerves palsy. He was referred to UMMC on 9 6 for an angiogram and was found to have the type `A' CCF. Upon injection of contrast into the Rt ICA, the Rt SOV was opacified. The Rt SOV was very engorged. No abnormal opacification of petrosal sinuses or cortical vessel.The Rt internal carotid clipping was performed on 28 7 98. However sad to say, post operatively there was no improvement. Another angiogram was performed in HUSM and was found to have a similar defect. Eventhough the Rt ICA was clipped, the collateral vessels from Rt vertebral artery have opened up to fill the ICA distal to the clip retrogradely. This will be explained in the poster. Direct sov cannulation and cut down was attempted via a right medial orbitotomy but failed to obtain good back flow from the vein. Results Subsequently the Rt ICA was directly punctured under an ultrasound guidance. 2 detachable silicone balloons and coils were placed in the CS. This was the first procedure performed in the North East Coast of West Malaysia. Current followup 6 months later revealed a patient whose bruit and exopthalmos has subsided. Conclusion Embolisation of recurrent post clipping CCF is difficult. Our patient was managed successfully via a combined team effort.
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Reach agreement, Sativex could reach pharmacies within a couple of months. GW says it will be applying for licences in "other Commonwealth countries", probably Australia and New Zealand. It may not be long before Sativex is joined by other cannabis preparations. A non-profit group, the Institute for Clinical Research in Berlin, Germany, is developing oral cannabis capsules, called Cannador. In November 2003 a study in 630 MS patients produced equivocal results The Lancet, vol 362, p 1517 ; . While the formal scoring system for measuring muscle spasticity indicated that Cannador performed no better than a placebo, the patients themselves felt it helped. Martin Schnelle, who conducted the trial, says that there are widely acknowledged problems with the formal scoring system used. "There are medicines that are already licensed for treating spasticity that have failed on this scale, " he says. The group is planning a further study this year in which the patients' reports will be the main measure by which the drug's effectiveness is judged. In the US, the NIDA has become more open to research on the benefits of cannabis, and Abrams is studying its ability to ease pain due to nerve damage in HIV, and nausea and vomiting after cancer chemotherapy. He is investigating a device called the Volcano, which heats cannabis to the point of vaporisation without burning it, which he says is less harmful than smoking it in a joint because it releases fewer carcinogens. While Abrams welcomes products like Sativex, he suggests that some people will always prefer marijuana to a commercial preparation - not least because they can grow it themselves. But however cultural attitudes to street or home-grown cannabis change, its availability in standardised, licensed preparations such as Sativex and perhaps Cannador will be the key to its wider medical use. GW is planning studies of its possible benefits for people with a range of conditions from Crohn's disease to rheumatoid arthritis and heroin addiction. If positive, Canada's decision will signal a big change in the status of cannabis, says Philip Robson, the firm's medical director. "It's the dawning of a new clinical research era.
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